To accurately interpret experiments that introduce additional mutations, an understanding of the somatic genetic profile and evolution of GEMM tumors is necessary. Genetically engineered mouse models (GEMMs) of cancer are increasingly being used to assess putative driver mutations identified by large-scale sequencing of human cancer genomes. Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, MA 02139 Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139 Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142 10 Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065. 8 Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724 Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724.

7 Department of Pathology, Tufts University School of Medicine and Veterinary Medicine, North Grafton, MA 01536.6 Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724.5 Bioinformatics Core, Memorial Sloan Kettering Cancer Center, New York, NY 10065.4 Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06510.Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, MA 02139. Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, MA 02139 2 Department of Pathology, Yale University School of Medicine, New Haven, CT 06510 Section of Medical Oncology, Department of Medicine, Yale University School of Medicine, New Haven, CT 06510 Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06510 3 David H.

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